Johnny Galecki, Jim Parsons, Kaley Cuoco, Simon Helberg, Kunal Nayyar
The show is centered on five people living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper, both physicists; Penny, a waitress and aspiring actress who lives across the hall; mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.
Over time, supporting characters have been promoted to starring roles: Leslie Winkle, a physicist colleague at Caltech and, at different times, a lover of both Leonard and Howard; Bernadette Rostenkowski, Howard's girlfriend (later his wife), a microbiologist and former part-time waitress alongside Penny; neuroscientist Amy Farrah Fowler, who joins the group after being matched to Sheldon on a dating website (and later becomes Sheldon's girlfriend), and Stuart Bloom, the cash-strapped owner of the comic book store the characters often visit.
The Big Bang Theory premiered on CBS on September 24, 2007. It's now in its seventh season which premiered on September 26, 2013.
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